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. 2007 Dec 15;3(4):128-33.
doi: 10.1186/1710-1492-3-4-128. Epub 2007 Dec 15.

Interleukin-12 peripheral blood levels in asthmatic children

Ruth Soferman  1 , Idit Rosenzwig, Elizabeth Fireman
Affiliations

Interleukin-12 peripheral blood levels in asthmatic children

Ruth Soferman et al. Allergy Asthma Clin Immunol. .

Abstract

: Interleukin-12 (IL-12) was measured in 45 asthmatic children aged 3 to 16 years. The assessments were performed on 20 children during an episode of acute exacerbation and on 25 children during remission. There was no significant difference between the mean IL-12 level during exacerbation (1.63 +/- 2.08 pg/mL) and during remission (0.88 +/- 0.56 pg/mL) (p = .83). A positive, but insignificant, correlation was found between forced expiratory volume in 1 second and IL-12 (p = .634). IL-12 levels were significantly lower in children with a positive family history of asthma (1.13 +/- 1.78 pg/mL) compared with those without (1.31 +/- 1.06 pg/mL) (p < .012), supporting the theory that the gene-environment interactions affect the immune responses. IL-12 peripheral blood levels had no detectable impact on the course of established asthma in the study population.

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Figures

Figure 1
Figure 1
Correlation of interleukin-12 levels to family history (Hx) of asthma. p < .012 (two-way ANOVA test).
Figure 2
Figure 2
Interleukin-12 (IL-12) peripheral blood levels versus forced expiratory volume in 1 second percent (FEV1%) predicted values. There were positive correlations between FEV1% predicted values and IL-12 peripheral blood levels, but they did not reach a level of significance (p = .6).
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