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. 2010 Jun 3;3(1):156.
doi: 10.1186/1756-0500-3-156.

Proinflammatory cytokine levels in fibromyalgia patients are independent of body mass index

Maria E Hernandez  1 , Enrique Becerril, Mayra Perez, Philippe Leff, Benito Anton, Sergio Estrada, Iris Estrada, Manuel Sarasa, Enrique Serrano, Lenin Pavon
Affiliations

Proinflammatory cytokine levels in fibromyalgia patients are independent of body mass index

Maria E Hernandez et al. BMC Res Notes. .

Abstract

Background: Fibromyalgia (FM) is characterized by chronic, widespread muscular pain and tenderness and is generally associated with other somatic and psychological symptoms. Further, circulatory levels of proinflammatory cytokines (IL-1beta, TNF-alpha, and IL-6) may be altered in FM patients, possibly in association with their symptoms. Recently, rises in BMI have been suggested to contribute to increased circulating levels of proinflammatory cytokines in FM patients. Our aim was to measure the circulatory levels of proinflammatory cytokines to determine the influence of BMI on these levels in FM patients and healthy volunteers (HVs). In Spanish FM patients (n = 64) and HVs (n = 25), we measured BMI and serum concentrations of proinflammatory cytokines by capture ELISA.

Findings: There were significant differences in BMI levels between FM patients (26.40 +/- 4.46) and HVs (23.64 +/- 3.45) and significant increase in IL-6 in FM patients (16.28 +/- 8.13 vs 0.92 +/- 0.32 pg/ml) (P < 0.001). IL-1beta and TNF-alpha decreased in FM patients compared with HVs. By ANCOVA, there was no significant association between BMI and TNF-alpha (F = 0.098, p = 0.75) or IL-6 (F = 0.221, p = 0.63) levels in FM patients.

Conclusions: Our analysis in FM patients of BMI as a covariate of proinflammatory cytokines levels showed that serum TNF-alpha and IL-6 levels are independent of BMI. Further studies are necessary to dissect these findings and their implication in future therapeutic approaches for FM patients.

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References

    1. Ozgocmen S. New strategies in evaluation of therapeutic efficacy in fibromyalgia syndrome. Curr Pharm Des. 2006;12:67–71. doi: 10.2174/138161206775193271. - DOI - PubMed
    1. Clauw DJ. Fibromyalgia: an overview. Am J Med. 2009;122:S3–S13. doi: 10.1016/j.amjmed.2009.09.006. - DOI - PubMed
    1. Lucas HJ, Brauch CM, Settas L, Theoharides TC. Fibromyalgia--new concepts of pathogenesis and treatment. Int J Immunopathol Pharmacol. 2006;19:5–10. - PubMed
    1. Salemi S, Rethage J, Wollina U, Michel BA, Gay RE, Gay S, Sprott H. Detection of interleukin lbeta (IL-lbeta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. J Rheumatol. 2003;30:146–150. - PubMed
    1. Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De FF, Ciapparelli A, Dell'Osso L, Bombardieri S. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol. 2007;25:225–230. - PubMed