Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Jul;12(7):640-1.
doi: 10.1038/ncb2076.

Nuclear transport receptor goes moonlighting

Oliver J Gruss
Comment

Nuclear transport receptor goes moonlighting

Oliver J Gruss. Nat Cell Biol. 2010 Jul.

Abstract

The importin-beta-like transport receptors and RanGTP govern selective transport of proteins into the nucleus. It has now been shown that importin-beta2 (alternatively called transportin1) also selectively targets the motor protein Kif17 to primary cilia. In analogy to the nucleus, RanGTP in the intraciliary compartment mediates dissociation of Kif17 from its transport receptor and thereby completes import.

PubMed Disclaimer

Comment on

References

    1. Nat Cell Biol. 2010 Jul;12(7):703-10 - PubMed
    1. J Cell Biol. 1996 Jun;133(5):985-96 - PubMed
    1. Cell. 2007 Jun 15;129(6):1201-13 - PubMed
    1. Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25 - PubMed
    1. Nat Genet. 2006 Sep;38(9):961-2 - PubMed

LinkOut - more resources