Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2010 Jul;42(7):576-8.
doi: 10.1038/ng.602. Epub 2010 Jun 6.

Common variants in FOXP1 are associated with generalized vitiligo

Ying Jin  1 , Stanca A Birlea, Pamela R Fain, Christina M Mailloux, Sheri L Riccardi, Katherine Gowan, Paulene J Holland, Dorothy C Bennett, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Mauro Picardo, Giovanni Leone, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Nanny van Geel, Jo Lambert, Andreas Overbeck, Richard A Spritz
Affiliations
Multicenter Study

Common variants in FOXP1 are associated with generalized vitiligo

Ying Jin et al. Nat Genet. 2010 Jul.

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).

PubMed Disclaimer

Conflict of interest statement

COMPETING INTERESTS STATEMENT

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Newly replicated associations in GV. Upper panel shows genomic control-corrected PLINK association results from the GWA scan for genotyped (black) and imputed (blue) SNPs on the y axis versus chromosomal nucleotide position (GRCh37) on the x axis surrounding (a) FOXP1 and (b) CCR6. Red squares indicate Cochran-Mantel-Haenszel combined P-values for the most strongly associated SNP in each locus. LD patterns for SNPs across the regions are shown below. Arrows indicate gene positions and transcriptional orientation. Lower panel shows pairwise r2 values for LD; darker boxes indicate stronger disequilibrium for SNPs in the upper panel.
Figure 1
Figure 1
Newly replicated associations in GV. Upper panel shows genomic control-corrected PLINK association results from the GWA scan for genotyped (black) and imputed (blue) SNPs on the y axis versus chromosomal nucleotide position (GRCh37) on the x axis surrounding (a) FOXP1 and (b) CCR6. Red squares indicate Cochran-Mantel-Haenszel combined P-values for the most strongly associated SNP in each locus. LD patterns for SNPs across the regions are shown below. Arrows indicate gene positions and transcriptional orientation. Lower panel shows pairwise r2 values for LD; darker boxes indicate stronger disequilibrium for SNPs in the upper panel.
See this image and copyright information in PMC

References

    1. Picardo M, Taïeb A, editors. Vitiligo. Springer; Heidelberg & New York: 2010.
    1. Alkhateeb A, et al. Pigment Cell Res. 2003;16:208–214. - PubMed
    1. Spritz RA. The genetics of generalized vitiligo. Curr Dir Autoimmun. 2008;10:244–257. - PubMed
    1. Jin Y, et al. New Engl J Med. 2010 Apr 21; Epub ahead of print 2010. - PubMed
    1. Purcell S, et al. Am J Hum Genet. 2008;81:559–775. - PubMed

Publication types

Substances