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. 2010 Feb 12;2010(34):611-616.
doi: 10.1039/b9nj00787c.

Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents

Zhaoda Zhang  1 , Andrew F Kolodziej, Jianfeng Qi, Shrikumar A Nair, Xifang Wang, April W Case, Matthew T Greenfield, Philip B Graham, Thomas J McMurry, Peter Caravan
Affiliations

Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents

Zhaoda Zhang et al. New J Chem. .

Abstract

A strategy for preparing high relaxivity, metabolically stable peptide-based MR contrast agents is described.

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Figures

Figure 1
Figure 1
NMRD showing field- and medium-dependent relaxivity of 5 at 35 °C in TBS buffer (open triangles), 30 μM human fibringogen/TBS (open circles), human plasma (filled triangles), and 30 μM fibrin gel (filled circles). NMRD of [Gd(DTPA)]2− in plasma (filled squares) shown for reference.
Figure 2
Figure 2
T1-weighted MR images of 5 in unclotted (A) and clotted (B) human plasma from a 1.5T clinical scanner (General Electric) with a 6 cm surface coil, using a spoiled gradient echo sequence (TE/TR/α: 3/39/40°)
Figure 3
Figure 3
Relaxometric analysis of 5: A) VT O-17 NMR (1/T1 open squares, 1/T2 filled squares) at 7.05T in TBS. VT NMRD in TBS (B) and fibrin gel (C) at 5° (open circles), 15° (filled circles), 25° (open triangles), and 35°C (filled triangles\). Solid lines are fits to data.
Scheme 1
Scheme 1
Compounds used in this study.
See this image and copyright information in PMC

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