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. 2010 May 25:6:219-23.
doi: 10.2147/tcrm.s7245.

Efficacy and safety of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis

Ege Can Serefoglu  1 , Zafer Tandogdu
Affiliations

Efficacy and safety of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis

Ege Can Serefoglu et al. Ther Clin Risk Manag. .

Abstract

Glucocorticoids are essential in treating many disorders and they are widely used in spite of their negative impact on the skeletal system. As bisphosphonates reduce bone resorption through their action on osteoclasts, they play an important role in management of glucocorticoid-induced osteoporosis. Unlike other bisphosphonates, zoledronic acid is given by intravenous infusion and it has a potential advantage of increasing the compliance and adherence of patients when it is given 5 mg once a year. However, this treatment modality seems to be associated with more adverse events than oral administrations, and further studies with longer follow-up periods must be conducted to determine the safety and cost-effectiveness of long-term treatment with zoledronic acid.

Keywords: bisphosphonates; glucocorticoids; osteoporosis; zoledronic acid.

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Figures

Figure 1
Figure 1
Percentage changes in BMD of lumbar spine in GIO patients treated with either daily risedronate or annual zoledronic acid (HORIZON). Abbreviations: BMD, bone mineral density; GIO, glucocorticoid-induced osteoporosis.
See this image and copyright information in PMC

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