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Case Reports
. 2010 Jul 15;51(2):185-8.
doi: 10.1086/653534.

Palivizumab-resistant human respiratory syncytial virus infection in infancy

Ortwin Adams  1 , Linda Bonzel, Alexander Kovacevic, Ertan Mayatepek, Thomas Hoehn, Markus Vogel
Affiliations
Case Reports

Palivizumab-resistant human respiratory syncytial virus infection in infancy

Ortwin Adams et al. Clin Infect Dis. .

Abstract

Palivizumab-resistant respiratory syncytial virus was isolated from an infant treated with palivizumab. A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab.

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