doi: 10.1111/j.1476-5381.1978.tb08471.x.
Vasoactive intestinal polypeptide promotes cyclic adenosine 3',5'-monophosphate accumulation in guinea-pig trachea
- PMID: 205290
- PMCID: PMC1668193
- DOI: 10.1111/j.1476-5381.1978.tb08471.x
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Vasoactive intestinal polypeptide promotes cyclic adenosine 3',5'-monophosphate accumulation in guinea-pig trachea
Br J Pharmacol.
1978 Mar.
Abstract
Cyclic adenosine 3',5'-monophosphage (cyclic AMP) levels in guinea-pig tracheal rings increased on incubation with the vasoactive intestinal peptide (VIP). The effect was potentiated by the addition of theophylline. The results suggest that the tracheo-bronchial relaxant action of VIP may be mediated by stimulation of tracheal adenylyl cyclase.
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