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Randomized Controlled Trial
. 2010 Aug;7(4):262-70.
doi: 10.1111/j.1742-481X.2010.00669.x. Epub 2010 May 31.

A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing

Hilde Beele  1 , Frans Meuleneire, Marc Nahuys, Steven L Percival
Affiliations
Randomized Controlled Trial

A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing

Hilde Beele et al. Int Wound J. 2010 Aug.

Abstract

The aim of this study was to observe both the clinical signs and symptoms of wounds at risk of infection, that is critically colonised (biofilm infected) and antimicrobial-performance of an ionic silver alginate/carboxymethylcellulose (SACMC) dressing, in comparison with a non silver calcium alginate fibre (AF) dressing, on chronic venous leg and pressure ulcers. Thirty-six patients with venous or pressure ulcers, considered clinically to be critically colonised (biofilm infected), were randomly chosen to receive either an SACMC dressing or a non silver calcium AF dressing. The efficacy of each wound dressing was evaluated over a 4-week period. The primary study endpoints were prevention of infection and progression to wound healing. The SACMC group showed a statistically significant (P = 0.017) improvement to healing as indicated by a reduction in the surface area of the wound, over the 4-week study period, compared with AF controls. In conclusion, the SACMC dressing showed a greater ability to prevent wounds progressing to infection when compared with the AF control dressing. In addition, the results of this study also showed an improvement in wound healing for SACMC when compared with a non silver dressing.

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Figures

Figure 1
Figure 1
Weighted wound progress analysis outcome for both study groups.
See this image and copyright information in PMC

References

    1. Kingsley A. The wound infection continuum and its application to clinical practice. Ostomy Wound Manage 2003;49(7A Suppl):1–7. - PubMed
    1. Sapico FL, Ginunas VJ, Thornhill‐Joynes M, Canawati HN, Capen DA, Klein NE, Khawam S Montgomerie JZ. Quantitative microbiology of pressure sores in different stages of healing. Diagn Microbiol Infect Dis 1986;5:31–8. - PubMed
    1. Stotts NA, Hunt TK. Pressure ulcers. Managing bacterial colonization and infection. Clin Geriatr Med 1997;13:565–73. - PubMed
    1. Wolcott RD, Dowd SE. A rapid molecular method for characterising bacterial bioburden in chronic wounds. J Wound Care 2008;17:513–6. - PubMed
    1. Wolcott RD, Rhoads DD, Dowd SE. Biofilms and chronic wound inflammation. J Wound Care 2008;17:333–41. - PubMed

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