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Review
. 1991 Jan;16(1):27-30.
doi: 10.1016/0968-0004(91)90012-k.

The granin (chromogranin/secretogranin) family

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Review

The granin (chromogranin/secretogranin) family

W B Huttner et al. Trends Biochem Sci. 1991 Jan.

Abstract

The chromogranins/secretogranins, referred to in abbreviated form as granins, are a family of acidic secretory proteins that are found in the secretory granules of a wide variety of endocrine cells and neurons, being stored together with many different peptide hormones and neuropeptides. The recent elucidation of their primary structure has provided insights into possible functions of these proteins. Moreover, the granins have been successfully used as markers for normal and neoplastic endocrine and neuronal cells, as well as model proteins to understand the sorting mechanism involved in the formation of secretory granules.

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