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. 2009 Oct;26(4):139-41.
doi: 10.4103/0970-2113.56351.

Nonseminomatous germ cell tumor with seizure disorder and mental retardation

Vinaya Karkhanis  1 , J M Joshi
Affiliations

Nonseminomatous germ cell tumor with seizure disorder and mental retardation

Vinaya Karkhanis et al. Lung India. 2009 Oct.

Abstract

We report a case of a patient who presented with anterior mediastinal mass, seizure disorder, and mental retardation. Computerized tomography-guided fine-needle aspiration biopsy of the mass showed nonseminomatous germ cell tumor. Chromosomal analysis showed XXY karyotype. A diagnosis of Klinefelter syndrome and mediastinal germ cell tumor was made.

Keywords: Klinefelter syndrome; Mediastinal germ cell tumors; nonseminomatous germ cell tumor.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
X-ray chest showing anterior mediastinal mass
Figure 2
Figure 2
Computed tomography thorax showing inhomogeneously enhancing mass lesion involving the entire right hemithorax
Figure 3
Figure 3
Photomicrograph (H and E, ×10 and ×20) of computed tomography-guided fine-needle aspiration cytology of the tumor showing cohesive clusters of tumor cells. Inset reveals vacuolated cytoplasm of tumor cells
Figure 4
Figure 4
Photomicrograph (H and E, ×20) showing hyaline basement membrane–like material within cell clusters
Figure 5
Figure 5
Chromosomal analysis
See this image and copyright information in PMC

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