Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jul;3(2):48-52.
doi: 10.4103/1658-354X.57872.

Effect of fluid preloading on postoperative nausea and vomiting following laparoscopic cholecystectomy

Ahmed Turkistani  1 , Khalid Abdullah, Essam Manaa, Bilal Delvi, Gamal Khairy, Badiah Abdulghani, Nancy Khalil, Fatma Damas, Abdelazeem El-Dawlatly
Affiliations

Effect of fluid preloading on postoperative nausea and vomiting following laparoscopic cholecystectomy

Ahmed Turkistani et al. Saudi J Anaesth. 2009 Jul.

Abstract

Background: Postoperative nausea and vomiting (PONV) is a common complication following general anesthesia. Different regimens have been described for the treatment of PONV with few that mention the prevention of it. Therefore, we conducted this study to compare the effect of preloading with either crystalloids or colloids on the incidence of PONV following laparoscopic cholecystectomy (LC), under general anesthesia.

Materials and methods: This study was carried out on 80 patients who underwent LC. The patients were divided into four groups (each 20 patients), to receive preloading of intravenous fluid, as follows: Group 1 received, 10 ml/kg of low-MW tetrastarch in saline (Voluven), group 2 received, 10 ml/kg medium-MW pentastarch in saline (Pentaspan), group 3, received 10 ml/kg of high-MW heta-starch in saline (Hespan), and group 4, received 10 ml/kg Lactated Ringer's, and this was considered as the control group. All patients received the standard anesthetic technique. The incidence of PONV was recorded, two and 24 hours following surgery. The need for antiemetics and/or analgesics was recorded postoperatively.

Results: The highest incidence of PONV was in group 3 (75% of the patients) compared to the other three groups. Also the same trend was found with regard to the number of patients who needed antiemetic therapy. It was the highest incidence in group 3 (70%), followed by group 2 (60%), and then group 1(35%), and the least one was in the control group (25%).

Conclusion: Intravascular volume deficits may be a factor in PONV and preloading with crystalloids showed a lower incidence of PONV.

Keywords: Crystalloid; colloids; general anesthesia; postoperative nausea and vomiting.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Total percentage of postoperative nausea and vomiting in studied groups
Figure 2
Figure 2
Patients who needed antiemetics
See this image and copyright information in PMC

References

    1. Cholwill JM, Wright W, Hobbs GJ, Curran J. Comparison of ondansetron and cyclizine for prevention of nausea and vomiting after day-case gynecological laparoscopy. Br J Anaesth. 1999;83:611–4. - PubMed
    1. Islam S, Jain PN. Post-operative nausea and vomiting (PONV): A review article. Indian J Anaesth. 2004;48:253–8.
    1. Cohen MM, Duncan PG, DeBoer DP, Tweed WA. The postoperative interview: Assessing risk factors for nausea and vomiting. Anesth Analg. 1994;78:7–16. - PubMed
    1. Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71. - PubMed
    1. Yogendran S, Asokumar B, Cheng DC, Chung F. A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery. Anesth Analg. 1995;80:682–6. - PubMed