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Case Reports
. 2010 Jun;77(6):693-4.
doi: 10.1007/s12098-010-0081-6. Epub 2010 Jun 8.

Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness

Sriram Krishnamurthy  1 , Anju Seth, Archana Puri, Rama Anand, Satinder Aneja
Affiliations
Case Reports

Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness

Sriram Krishnamurthy et al. Indian J Pediatr. 2010 Jun.

Abstract

A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.

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