Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul;21(7):2115-24.
doi: 10.1007/s10856-010-4072-y. Epub 2010 Jun 9.

Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration

Ulrike Assmann  1 , Andreas Szentivanyi, Yvonne Stark, Thomas Scheper, Silke Berski, Gerald Dräger, Robert H Schuster
Affiliations

Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration

Ulrike Assmann et al. J Mater Sci Mater Med. 2010 Jul.

Abstract

Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-alpha-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-alpha-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.

PubMed Disclaimer

References

    1. Biomaterials. 2008 May;29(13):1989-2006 - PubMed
    1. Mol Cell Neurosci. 2009 Mar;40(3):374-81 - PubMed
    1. Biochimie. 2001 Jul;83(7):635-43 - PubMed
    1. J Biomed Mater Res. 2002 Jun 15;60(4):613-21 - PubMed
    1. Biomaterials. 2005 May;26(15):2603-10 - PubMed

Publication types

LinkOut - more resources