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. 2010 Sep;11(3):1038-44.
doi: 10.1208/s12249-010-9459-z. Epub 2010 Jun 9.

Formulation and evaluation of buccal patches for delivery of atenolol

Surya N Ratha Adhikari  1 , Bhabani S Nayak, Amit K Nayak, Biswaranjan Mohanty
Affiliations

Formulation and evaluation of buccal patches for delivery of atenolol

Surya N Ratha Adhikari et al. AAPS PharmSciTech. 2010 Sep.

Abstract

Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 P, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. All these fabricated patches were sustained for 24 h and obeyed first-order release kinetics. Ex vivo drug permeation study was also performed using porcine buccal mucosa, and various drug permeation parameters like flux and lag time were determined.

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Figures

Fig. 1
Fig. 1
The cross sectional SEM microphotograph of various atenolol-containing buccal patches (a F 2, b F 8, and c F 11)
Fig. 2
Fig. 2
a In vitro drug release profile of various atenolol-containing buccal patches (F 1 to F 6). b In vitro drug release profile of various atenolol-containing buccal patches (F 7 to F 14)
Fig. 3
Fig. 3
a Ex vivo drug permeation profile of various atenolol-containing buccal patches (F 1 to F 6). b Ex vivo drug permeation profile of various atenolol-containing buccal patches (F 7 to F 14)
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