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Comment
. 2010 May 28;17(5):417-8.
doi: 10.1016/j.chembiol.2010.05.002.

HAT trick: p300, small molecule, inhibitor

Melanie Ott  1 , Eric Verdin
Affiliations
Comment

HAT trick: p300, small molecule, inhibitor

Melanie Ott et al. Chem Biol. .

Abstract

p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications.

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