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Comparative Study
. 2011 Jan:31 Suppl 3:321-3.
doi: 10.1007/s10072-010-0351-0.

Natalizumab efficacy on cognitive impairment in MS

F Mattioli  1 , C Stampatori, F Bellomi, R Capra
Affiliations
Comparative Study

Natalizumab efficacy on cognitive impairment in MS

F Mattioli et al. Neurol Sci. 2011 Jan.

Abstract

We report follow-up data on the efficacy of natalizumab therapy on neuropsychological impairment on an italian MS group of 39 patients at 1 year and of 11 patients at 2 years. Results show a significant reduction in relapse rate, in the number of impaired neuropsychological tests as well as in several single executive function and reasoning tests scores at 1 year. Improvement persisted at 2 years, including also memory and speed processing tasks. These data support the efficacy of natalizumab therapy in all the clinical domains, including cognitive deterioration, in multiple sclerosis patients.

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