Review
[Meiotic inactivation of sex chromosomes in mammals]
[Article in
Russian]
- PMID: 20536013
Item in Clipboard
Review
[Meiotic inactivation of sex chromosomes in mammals]
[Article in
Russian]
Genetika.
2010 Apr.
Abstract
During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X chromosome preserve inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which his observed in mammalian females at early embryogenetic stages.
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