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Review
. 2010 Apr;46(4):437-47.

[Meiotic inactivation of sex chromosomes in mammals]

[Article in Russian]
E A Vas'kova, S V Pavlova, A I Shevchenko, S M Zakinian
  • PMID: 20536013
Review

[Meiotic inactivation of sex chromosomes in mammals]

[Article in Russian]
E A Vas'kova et al. Genetika. 2010 Apr.

Abstract

During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X chromosome preserve inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which his observed in mammalian females at early embryogenetic stages.

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