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Comment
. 2010 Sep;58(3):e29-30; author reply e31-2.
doi: 10.1016/j.eururo.2010.05.003. Epub 2010 May 18.

Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8

Arun Sreekumar, Laila M Poisson, Thekkelnaycke M Rajendiran, Amjad P Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J Lonigro, Yong Li, Mukesh K Nyati, Aarif Ahsan, Shanker Kalyana-Sundaram, Bo Han, Xuhong Cao, Jaeman Byun, Gilbert S Omenn, Debashis Ghoshd, Subramaniam Pennathur, Danny C Alexander, Alvin Berger, Jeffrey R Shuster, John T Wei, Sooryanarayana Varambally, Christopher Beecher, Arul M Chinnaiyan
Comment

Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8

Arun Sreekumar et al. Eur Urol. 2010 Sep.
No abstract available

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Conflict of interest statement

Conflicts of interest: Christopher Beecher was previously an employee of Metabolon. Christopher Beecher, Danny C. Alexander, Jeffrey R. Shuster, and Alvin Berger own equity in Metabolon. Arul M. Chinnaiyan joined the scientific advisory board of Metabolon in July 2008. The University of Michigan has licensed the diagnostic field of use of the metabolomic biomarkers discussed in this manuscript to Metabolon (Arul M. Chinnaiyan and Arun Sreekumar are named as inventors).

Figures

Fig. 1
Fig. 1
Box plot of sarcosine levels based on isotope-dilution gas chromatography–mass spectrometry analysis showing median sarcosine-to-alanine levels in urine sediments from an independent group of biopsy-positive and -negative individuals.
See this image and copyright information in PMC

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References

    1. Jentzmik F, Stephan C, Miller K, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumors. Eur Urol. 2010;58:12–8. - PubMed
    1. Sreekumar A, Poisson LM, Rajendiran TM, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457:910–4. - PMC - PubMed