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Randomized Controlled Trial
. 2010 Sep 1;111(1-2):114-9.
doi: 10.1016/j.drugalcdep.2010.04.011. Epub 2010 May 26.

The role of alcohol misuse in PTSD outcomes for women in community treatment: a secondary analysis of NIDA's Women and Trauma Study

Denise A Hien  1 , Aimee N C Campbell, Lesia M Ruglass, Mei-Chen Hu, Therese Killeen
Affiliations
Randomized Controlled Trial

The role of alcohol misuse in PTSD outcomes for women in community treatment: a secondary analysis of NIDA's Women and Trauma Study

Denise A Hien et al. Drug Alcohol Depend. .

Abstract

Background: Individuals with comorbid substance use and posttraumatic stress disorder may differentially benefit from integrated trauma-focused interventions based on specific presenting characteristics such as substance use type and PTSD severity. The current study is a secondary analysis of a NIDA Clinical Trials Network study exploring the effectiveness of two interventions for women with comorbid PTSD and substance use disorders.

Method: Generalized estimating equations were used to examine the association of baseline alcohol misuse with PTSD outcome measures over time for all randomized participants.

Results: Women entering treatment with baseline alcohol misuse had higher Post Traumatic Stress Disorder Symptom Scale (PSS-SR) total scores (t=2.43, p<.05), cluster C (avoidance/numbing) scores (t=2.63, p<.01), and cluster D (hyper-arousal) scores (t=2.31, p<.05). For women with alcohol misuse, after treatment week 1, PSS-SR scores were significantly lower in the Seeking Safety intervention during treatment (chi(2)(1)=4.00, p<.05) and follow-up (chi(2)(1)=4.87, p<.05) compared to those in the health education intervention. Alcohol misusers in the Seeking Safety group who had higher baseline hyper-arousal severity improved more quickly than those with lower baseline hyper-arousal severity during treatment (chi(2)(1)=4.06, p<.05).

Conclusions: These findings suggest that the type of substance abuse at treatment entry may inform treatment selection, predict treatment response among those with co-occurring PTSD and substance use disorders, and indicate a more severe clinical picture.

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Figures

Figure 1
Figure 1
PSS-SR Total Severity by Baseline Alcohol Misuse and Treatment Type (Seeking Safety vs. Women’s Health Education).
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References

    1. Back SE, Brady KT, Sonne SC, Verduin ML. Symptom improvement in co-occurring PTSD and alcohol dependence. J Ment Dis. 2006;194(9):690–696. - PubMed
    1. Back SE, Sonne SC, Killeen TK, Dansky BS, Brady KT. Comparative profiles of women with PTSD and comorbid cocaine or alcohol dependence. Am J Drug Alcohol Abuse. 2003;29(1):169–189. - PubMed
    1. Brady KT, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM. Effcacy and safety of sertraline treatment of post-traumatic stress disorder: a randomized controlled trial. JAMA. 2000;283:1837–1844. - PubMed
    1. Brady KT, Sonne S, Anton RF, Randall LC, Back SE, Simpson K. Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcohol Clin Exp Res. 2005;29(3):395–401. - PubMed
    1. Courtois CA, Ford JD, van der Kolk BA. Treating Complex Traumatic Stress Disorder. Guilford, New York: 2009.

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