Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism
- PMID: 20538072
- PMCID: PMC2911127
- DOI: 10.1016/j.bbalip.2010.06.002
Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism
Abstract
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-OSTbeta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OSTalpha-OSTbeta in the compartmentalization and metabolism of these important lipids.
2010 Elsevier B.V. All rights reserved.
Figures





Similar articles
-
OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.Hepatology. 2005 Dec;42(6):1270-9. doi: 10.1002/hep.20961. Hepatology. 2005. PMID: 16317684
-
The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.J Biol Chem. 2005 Feb 25;280(8):6960-8. doi: 10.1074/jbc.M412752200. Epub 2004 Nov 24. J Biol Chem. 2005. PMID: 15563450 Free PMC article.
-
Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G179-G186. doi: 10.1152/ajpgi.90319.2008. Epub 2008 May 22. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18497332 Free PMC article.
-
Pleiotropic functions of the organic solute transporter Ostα-Ostβ.Dig Dis. 2011;29(1):13-7. doi: 10.1159/000324123. Epub 2011 Jun 17. Dig Dis. 2011. PMID: 21691099 Free PMC article. Review.
-
Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.Semin Liver Dis. 2010 May;30(2):178-85. doi: 10.1055/s-0030-1253226. Epub 2010 Apr 26. Semin Liver Dis. 2010. PMID: 20422499 Free PMC article. Review.
Cited by
-
Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering.Foods. 2021 Nov 2;10(11):2666. doi: 10.3390/foods10112666. Foods. 2021. PMID: 34828946 Free PMC article. Review.
-
Bile acids are nutrient signaling hormones.Steroids. 2014 Aug;86:62-8. doi: 10.1016/j.steroids.2014.04.016. Epub 2014 May 10. Steroids. 2014. PMID: 24819989 Free PMC article. Review.
-
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.Gastroenterology. 2014 Apr;146(4):1006-16. doi: 10.1053/j.gastro.2013.12.029. Epub 2013 Dec 31. Gastroenterology. 2014. PMID: 24389307 Free PMC article.
-
Maize ZmLAZ1-3 gene negatively regulates drought tolerance in transgenic Arabidopsis.BMC Plant Biol. 2024 Apr 5;24(1):246. doi: 10.1186/s12870-024-04923-x. BMC Plant Biol. 2024. PMID: 38575869 Free PMC article.
-
Fat Malabsorption and Ursodeoxycholic Acid Treatment in Children With Reduced Organic Solute Transporter-α (SLC51A) Expression.JPGN Rep. 2022 Aug;3(3):e229. doi: 10.1097/pg9.0000000000000229. Epub 2022 Jul 25. JPGN Rep. 2022. PMID: 36148443 Free PMC article.
References
-
- Lin MC, Weinberg SL, Kramer W, Burckhardt G, Wilson FA. Identification and comparison of bile acid-binding polypeptides in ileal basolateral membrane. J Membr Biol. 1988;106:1–11. - PubMed
-
- Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3) J Biol Chem. 2000;275:2905–2910. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources