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Comparative Study
. 2010 Aug;31(8):1284-303.
doi: 10.1016/j.neurobiolaging.2010.05.003. Epub 2010 Jun 11.

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

Liana G Apostolova  1 , Kristy S Hwang, John P Andrawis, Amity E Green, Sona Babakchanian, Jonathan H Morra, Jeffrey L Cummings, Arthur W Toga, John Q Trojanowski, Leslie M Shaw, Clifford R Jack Jr, Ronald C Petersen, Paul S Aisen, William J Jagust, Robert A Koeppe, Chester A Mathis, Michael W Weiner, Paul M Thompson; Alzheimer's Disease Neuroimaging Initiative
Affiliations
Comparative Study

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

Liana G Apostolova et al. Neurobiol Aging. 2010 Aug.

Abstract

Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab(42), total tau (t-tau) and phosphorylated tau (p-tau(181)) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab(42), t-tau, p-tau(181), t-tau/Ab(42) and p-tau(181)/Ab(42). All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau(181), followed by p-tau(181)/Ab(42) ratio, t-tau/Ab(42) ratio, t-tau and Ab(42). p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy.

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Figures

Fig. 1
Fig. 1
Three-dimensional (3D) statistical maps of the associations between cerebrospinal fluid (CSF) biomarkers and hippocampal radial distance (for areas in red and white p < 0.05). For permutation corrected significance values see Table 2.
Fig. 2
Fig. 2
Three-dimensional (3D) statistical maps of the associations between cerebrospinal fluid (CSF) biomarkers and hippocampal radial distance in normal control (NC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) (for areas in red and white p < 0.05).
Fig. 3
Fig. 3
Three-dimensional (3D) statistical maps of the associations between cerebrospinal fluid (CSF) biomarkers and hippocampal radial distance in ApoE4 carriers and noncarriers (for areas in red and white p < 0.05).
Fig. 4
Fig. 4
Three-dimensional (3D) statistical maps of the associations between cerebrospinal fluid (CSF) biomarkers and hippocampal radial distance in ApoE4 carriers and noncarriers within each diagnostic category (for areas in red and white p < 0.05).
Fig. 5
Fig. 5
Cumulative distribution function (CDF) plots comparing the strengths of the associations between the cerebrospinal fluid (CSF) biomarker measures and hippocampal radial distance in the pooled sample (A) and in each diagnostic group (B). The y = 20× line denotes the threshold that controls the allowed 5% false discovery rate (FDR) (i.e., the maximum proportion of false positives allowed, by convention, for a map to be declared significant overall).
Fig. 6
Fig. 6
Three-dimensional (3D) statistical maps of the associations between the 3 Pittsburgh Compound B (PIB) biomarkers and hippocampal radial distance (for areas in red and white p < 0.05).
Fig. 7
Fig. 7
Three-dimensional (3D) statistical maps of the associations between Pittsburgh Compound B (PIB) biomarkers and hippocampal radial distance in ApoE4 carriers and noncarriers (for areas in red and white p < 0.05).
Fig. 8
Fig. 8
Three-dimensional (3D) statistical maps of the associations between cerebrospinal fluid (CSF) amyloid beta (Aβ)42 and the 3 Pittsburgh Compound B (PIB) biomarkers and hippocampal radial distance in the combined CSF/PIB sample (for areas in red and white p < 0.05).
See this image and copyright information in PMC

References

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