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Comment
. 2010 Jul 15;16(14):3523-5.
doi: 10.1158/1078-0432.CCR-10-1201. Epub 2010 Jun 10.

PIKing the right patient

Alexa B Turke  1 , Jeffrey A Engelman
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Comment

PIKing the right patient

Alexa B Turke et al. Clin Cancer Res. .

Abstract

HER2 amplification and PIK3CA mutation were validated as biomarkers for sensitivity to the single-agent phosphoinositide 3-kinase (PI3K) inhibitor, GDC-0941, in breast cancer models. A novel expression profile was developed to identify other breast cancers sensitive to PI3K inhibitors. These expression studies highlighted feedback networks connecting TORC1, PI3K, and mitogen-activated protein kinase (MAPK) pathways, and underscored the potential for combination therapies.

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