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Case Reports
. 2010 Sep;31(8):E69-70; author reply E71.
doi: 10.3174/ajnr.A2160. Epub 2010 Jun 10.

Proton MR spectroscopy of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome

V Cuvinciuc, G Martin-Blondel, B Marchou, F Bonneville
Case Reports

Proton MR spectroscopy of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome

V Cuvinciuc et al. AJNR Am J Neuroradiol. 2010 Sep.
No abstract available

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Figures

Fig 1.
Fig 1.
A, Fluid-attenuated inversion recovery (FLAIR) axial image shows high signal intensity in the left corona radiata, compatible with PML. Note the right frontal postsurgical appearance after evacuation of a cerebral abscess. B, Short TE spectroscopy shows increased Cho, free lipids (and/or Lac), and diminished NAA. C, After 2 months of treatment, with adapted biologic response but paradoxic clinical worsening, axial FLAIR image reveals an enlargement of the left T2 hyperintensity with obvious mass effect on the ipsilateral ventricle. D, Short TE spectroscopy shows further increase in Cho, Lac, and free lipid peaks (long TE not shown). Glx indicates glutamine/glutamate; lip, lipid; mI, myo-inositol.
See this image and copyright information in PMC

Comment on

  • JC virus infection of the brain.
    Bag AK, Curé JK, Chapman PR, Roberson GH, Shah R. Bag AK, et al. AJNR Am J Neuroradiol. 2010 Oct;31(9):1564-76. doi: 10.3174/ajnr.A2035. Epub 2010 Mar 18. AJNR Am J Neuroradiol. 2010. PMID: 20299430 Free PMC article.

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References

    1. Bag AK, Cure JK, Chapman PR, et al. . JC virus infection of the brain. AJNR Am J Neuroradiol 2010. March 18. [Epub ahead of print] - PMC - PubMed
    1. Tan K, Roda R, Ostrow L, et al. . PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology 2009;72:1458–64 - PMC - PubMed
    1. Katz-Brull R, Lenkinski RE, Du Pasquier RA, et al. . Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology 2004;63:897–900 - PubMed

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