Gut-brain cross-talk in appetite regulation

Abstract

Purpose of review: To review the role of gut hormones involved in appetite regulation and their potential in the treatment of obesity.

Recent findings: The medical treatment of obesity has been fraught with challenges. With two centrally acting agents having been recently withdrawn from the market, new therapies are required. The gut hormones are especially promising therapeutic targets. This article looks at the interplay between gut and brain which mediates the regulation of appetite and energy expenditure. Some recent developments that point the way towards the future development of gut hormone analogues as treatments for obesity are reviewed.

Summary: Our understanding of the interaction between gut hormones and the neuronal circuits controlling appetite regulation has made great advances over recent years. This knowledge is essential if these peptides are to become potential obesity therapies, both from an efficacy and safety perspective.