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Comment
. 2010 Jun 15;17(6):527-9.
doi: 10.1016/j.ccr.2010.05.016.

LKB1 and Src: antagonistic regulators of tumor growth and metastasis

Jill Slack-Davis  1 , John O Dasilva, Sarah J Parsons
Affiliations
Free article
Comment

LKB1 and Src: antagonistic regulators of tumor growth and metastasis

Jill Slack-Davis et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Carretero and colleagues report that Src and FAK signaling pathways are activated in lung cancers when the tumor suppressor LKB1 is deleted. These findings suggest the use of unique combinatorial therapies for treatment of lung cancers.

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  • Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
    Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK. Carretero J, et al. Cancer Cell. 2010 Jun 15;17(6):547-59. doi: 10.1016/j.ccr.2010.04.026. Cancer Cell. 2010. PMID: 20541700 Free PMC article.

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