doi: 10.1007/BF01935940.
Neuronal responses to extracellularly applied cyclic AMP:Role of the adenosine receptor
- PMID: 205430
- DOI: 10.1007/BF01935940
Item in Clipboard
Neuronal responses to extracellularly applied cyclic AMP:Role of the adenosine receptor
Experientia.
.
Abstract
At low doses, theophylline blocks the neuronal depressant effects of 5'-AMP, but not cyclic AMP. Higher doses (100 mg/kg) block cyclic AMP responses and reduce the effects of noradrenaline and GABA. It is concluded that cyclic AMP does not depress neurones via the adenosine receptor.
Similar articles
-
Microiontophoretic studies of the effects of cylic nucleotides on excitability of neurones in the rat cerebral cortex.J Physiol. 1977 Apr;266(3):523-43. doi: 10.1113/jphysiol.1977.sp011780. J Physiol. 1977. PMID: 194028 Free PMC article.
-
Evidence against cyclic adenosine 3',5'-monophosphate (AMP) mediation of noradrenaline depression of cerebral cortical neurones.Brain Res. 1973 Oct 12;60(2):411-21. doi: 10.1016/0006-8993(73)90799-3. Brain Res. 1973. PMID: 4357896 No abstract available.
-
Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex.Neurosci Lett. 1979 Jan;11(1):93-7. doi: 10.1016/0304-3940(79)90062-4. Neurosci Lett. 1979. PMID: 431890
-
Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex.Can J Physiol Pharmacol. 1977 Feb;55(1):130-3. doi: 10.1139/y77-020. Can J Physiol Pharmacol. 1977. PMID: 843988
-
Regulation of cyclic AMP content in normal and malignant brain cells.Adv Cyclic Nucleotide Res. 1975;5:641-58. Adv Cyclic Nucleotide Res. 1975. PMID: 165690 Review.
Cited by
-
Antagonism by clonidine of neuronal depressant responses to adenosine, adenosine-5'-monophosphate and adenosine triphosphate.Br J Pharmacol. 1978 Nov;64(3):369-74. doi: 10.1111/j.1476-5381.1978.tb08659.x. Br J Pharmacol. 1978. PMID: 719233 Free PMC article.
-
Adenine nucleotides and synaptic transmission in the in vitro rat hippocampus.Br J Pharmacol. 1980 May;69(1):59-68. doi: 10.1111/j.1476-5381.1980.tb10883.x. Br J Pharmacol. 1980. PMID: 6247005 Free PMC article.
-
Blockade of striatal neurone responses to morphine by aminophylline: evidence for adenosine mediation of opiate action.Br J Pharmacol. 1980 May;69(1):131-7. doi: 10.1111/j.1476-5381.1980.tb10892.x. Br J Pharmacol. 1980. PMID: 7378652 Free PMC article.
-
Characteristics of the release of adenosine from slices of rat cerebral cortex.J Physiol. 1980 Jun;303:73-82. doi: 10.1113/jphysiol.1980.sp013271. J Physiol. 1980. PMID: 7431247 Free PMC article.
-
Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.Br J Pharmacol. 1980 May;69(1):107-12. doi: 10.1111/j.1476-5381.1980.tb10888.x. Br J Pharmacol. 1980. PMID: 7378648 Free PMC article.