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. 2010 Jan;17(1):60-2.
doi: 10.4103/0974-9233.61218.

What is Central Toxic Keratopathy Syndrome if it is not Diffuse lamellar Keratitis Grade IV?

Ribhi Hazin  1 , Yassine J Daoud, Yousuf M Khalifa
Affiliations

What is Central Toxic Keratopathy Syndrome if it is not Diffuse lamellar Keratitis Grade IV?

Ribhi Hazin et al. Middle East Afr J Ophthalmol. 2010 Jan.

Abstract

The Central Toxic Keratopathy (CTK) syndrome describes a rare, acute, self-limited, non-inflammatory process that yields central corneal opacification and significant hyperopic shift after refractive surgery. Despite being exceedingly rare, certain clinical features of CTK give the condition a striking resemblance to other more serious inflammatory conditions, including diffuse lamellar keratitis (DLK). As the authors demonstrate in this article, despite the overlapping clinical features, CTK is a disease process that is distinct from DLK and, therefore, in need of distinct management interventions.

Keywords: Central toxic keratopathy; Laser in situ keratomileusis; PRK; diffuse lamellar keratitis; keratitis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Characteristic loss of corneal clarity in CTK. Image Courtesy of Majid Moshirfar, M.D.
Figure 2
Figure 2
A Pentacam image revealing significant central thinning and keratometric flattening in a patient with CTK. Image Courtesy of Majid Moshirfar, M.D.
See this image and copyright information in PMC

References

    1. Moshirfar M, Hazin R, Khalifa YM. Central Toxic Keratopahy. Curr Opin Ophthalmol. 2010;7:2. - PubMed
    1. Smith RJ, Maloney RK. Diffuse lamellar keratitis: A new syndrome in lamellar refractive surgery. Ophthalmology. 1998;105:1721–6. - PubMed
    1. Sonmez B, Maloney RK. Central toxic keratopathy: Description of a syndrome in laser refractive surgery. Am J Ophthalmol. 2007;143:420–7. - PubMed
    1. Mirshahi A, Baatz H. Posterior segment complications of laser in situ keratomileusis (LASIK) Surv Ophthalmol. 2009;54:433–40. - PubMed
    1. Hadden OB, McGhee CN, Morris AT, Gray TB, Ring CP, Watson AS. Outbreak of diffuse lamellar keratitis caused by marking-pen toxicity. J Cataract Refract Surg. 2008;34:1121–4. - PubMed