Review
doi: 10.1016/j.drudis.2010.05.003.
Epub 2010 Jun 1.
Calcium phosphate biomaterials as bone drug delivery systems: a review
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- PMID: 20546919
- DOI: 10.1016/j.drudis.2010.05.003
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Review
Calcium phosphate biomaterials as bone drug delivery systems: a review
Drug Discov Today.
2010 Jul.
Abstract
A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Experimental works performed for local delivery are reported. In particular, a description is given of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.
2010 Elsevier Ltd. All rights reserved.
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