Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep 14;226(1-2):147-9.
doi: 10.1016/j.jneuroim.2010.05.035. Epub 2010 Jun 12.

HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Marieke T de Graaf  1 , Janet W K de Beukelaar, Geert W Haasnoot, Wilfried H B M Levering, Véronique Rogemond, Adrien Didelot, Jérôme Honnorat, Jan W Gratama, Peter A E Sillevis Smitt
Affiliations

HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Marieke T de Graaf et al. J Neuroimmunol. .

Abstract

Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).

Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells.

Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).

Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.

Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources