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Review
. 2010 Nov 9;182(16):1749-53.
doi: 10.1503/cmaj.090548. Epub 2010 Jun 14.

Substituting placebo for established, effective therapy: why not?

Stan Shapiro  1 , Dean Fergusson, Kathleen Cranley Glass
Affiliations
Review

Substituting placebo for established, effective therapy: why not?

Stan Shapiro et al. CMAJ. .
No abstract available

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Figures

Figure 1
Figure 1
Basic logic for choice of control group, as proposed by the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. The shading highlights the recommendations regarding use of placebo in the presence of proven effective treatment. *Add-on, replacement, early escape, brief placebo period and randomized withdrawal. Reproduced, with permission, from International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (E-10). The section numbers appearing in the figure refer to section numbers in the source document.
See this image and copyright information in PMC

References

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    1. Council for International Organizations of Medical Sciences. International guidelines for biomedical research involving human subjects. Geneva (Switzerland): The Council; 2002. - PubMed
    1. Choice of control group and related issues in clinical trials (E-10) Geneva (Switzerland): International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; 2000.
    1. Temple R, Ellenberg S. Placebo-controlled trials and active-controlled trials in the evaluation of new treatments. Part1: Ethical and scientific issues. Ann Intern Med. 2000;133:455–63. - PubMed

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