Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;54(8):3512-5.
doi: 10.1128/AAC.01646-09. Epub 2010 Jun 14.

Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France

Didier Hocquet  1 , Patrick Plésiat, Barbara Dehecq, Pierre Mariotte, Daniel Talon, Xavier Bertrand; ONERBA
Collaborators, Affiliations

Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France

Didier Hocquet et al. Antimicrob Agents Chemother. 2010 Aug.

Abstract

A nationwide study aimed to identify the extended-spectrum beta-lactamases (ESBLs), metallo-beta-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates highly resistant to ceftazidime. Six ESBLs (PER-1, n=3; SHV-2a, n=2; VEB-1a, n=1), four MBLs (VIM-2, n=3; IMP-18, n=1), and five ES-OXAs (OXA-19, n=4; OXA-28, n=1) were identified in 13 isolates (9.3% of the collection). The prevalence of these enzymes is still low in French clinical P. aeruginosa isolates but deserves to be closely monitored.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Map of France, showing the 85 sites included in the study and the localization of isolates of P. aeruginosa producing ESBLs, MBLs, and ES-OXAs. An enlarged map of the Ile-de-France region is provided at the upper left. Labels indicate the town of isolation, the nature of the enzymes, and the number of isolates.
See this image and copyright information in PMC

References

    1. al Naiemi, N., B. Duim, and A. Bart. 2006. A CTX-M extended-spectrum β-lactamase in Pseudomonas aeruginosa and Stenotrophomonas maltophilia. J. Med. Microbiol. 55:1607-1608. - PubMed
    1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410. - PubMed
    1. Arlet, G., and A. Philippon. 1991. Construction by polymerase chain reaction and use of intragenic DNA probes for three main types of transferable β-lactamases (TEM, SHV, CARB). FEMS Microbiol. Lett. 66:19-25. - PubMed
    1. Azim, A., M. Dwivedi, P. B. Rao, A. K. Baronia, R. K. Singh, K. N. Prasad, B. Poddar, A. Mishra, M. Gurjar, and T. N. Dhole. 2010. Epidemiology of bacterial colonization at ICU admission with emphasis on extended-spectrum β-lactamases and metallo-β-lactamase producing gram-negative bacteria—an Indian experience. J. Med. Microbiol. doi:10.1099/jmm.0.018085-0. - DOI - PubMed
    1. Babini, G. S., and D. M. Livermore. 2000. Are SHV β-lactamases universal in Klebsiella pneumoniae? Antimicrob. Agents Chemother. 44:2230. - PMC - PubMed

Publication types

MeSH terms