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Comment
. 2010 Jun 22;107(25):11153-4.
doi: 10.1073/pnas.1006673107. Epub 2010 Jun 14.

A big role for small RNAs in influenza virus replication

Margaret A Scull  1 , Charles M Rice
Affiliations
Comment

A big role for small RNAs in influenza virus replication

Margaret A Scull et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Simplified schematic of the influenza-virus life cycle. Green lines represent negative-sense RNA; orange lines represent positive-sense RNA. RdRp, RNA-dependent RNA polymerase. svRNAs, as described in PNAS (1), are key regulators of vRNA replication (additional details in text).
See this image and copyright information in PMC

Comment on

References

    1. Perez JT, et al. Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci USA. 2010 10.1073/pnas.1001984107. - PMC - PubMed
    1. Neumann G, Brownlee GG, Fodor E, Kawaoka Y. Orthomyxovirus replication, transcription, and polyadenylation. Curr Top Microbiol Immunol. 2004;283:121–143. - PubMed
    1. Hsu MT, Parvin JD, Gupta S, Krystal M, Palese P. Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc Natl Acad Sci USA. 1987;84:8140–8144. - PMC - PubMed
    1. Barrett T, Wolstenholme AJ, Mahy BW. Transcription and replication of influenza virus RNA. Virology. 1979;98:211–225. - PubMed
    1. Krug RM, Ueda M, Palese P. Temperature-sensitive mutants of influenza WSN virus defective in virus-specific RNA synthesis. J Virol. 1975;16:790–796. - PMC - PubMed

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