doi: 10.1093/genetics/88.2.327.
X-linked and autosomal genes controlling mouse alpha-galactosidase expression
- PMID: 205481
- PMCID: PMC1213804
- DOI: 10.1093/genetics/88.2.327
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X-linked and autosomal genes controlling mouse alpha-galactosidase expression
Genetics.
1978 Feb.
Abstract
Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse alpha-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of alpha-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.
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