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Case Reports
. 2010 Sep;30(3):255-9.
doi: 10.1097/WNO.0b013e3181dee96c.

Orbital involvement in Bing-Neel syndrome

Rebecca C Stacy  1 , Frederick A Jakobiec, Fred H Hochberg, Ephraim P Hochberg, Dean M Cestari
Affiliations
Case Reports

Orbital involvement in Bing-Neel syndrome

Rebecca C Stacy et al. J Neuroophthalmol. 2010 Sep.

Abstract

Bing-Neel syndrome (BNS) is defined as intracranial involvement of Waldenström macroglobulinemia (WM). Few cases of orbital involvement have been reported. A 51-year-old man with a history of WM developed bilateral orbitopathy and optic neuropathy. Orbital biopsy, cerebrospinal fluid studies, and neuroimaging confirmed the diagnosis of BNS involving the orbital soft tissues, optic nerves, meninges, and cauda equina. The neuro-ophthalmic manifestations resolved after parenteral and intrathecal chemotherapy in addition to autologous stem cell transplantation. The rare neuro-ophthalmic manifestations of BNS may require a multifaceted approach to therapy.

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Comment in

  • Orbital involvement in Bing-Neel syndrome.
    Doshi RR, Silkiss RZ, Imes RK. Doshi RR, et al. J Neuroophthalmol. 2011 Mar;31(1):94-5. doi: 10.1097/WNO.0b013e31820ecbc1. J Neuroophthalmol. 2011. PMID: 21317736 No abstract available.

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