Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;37(3):322-3.

Update on hypertrophic cardiomyopathy

Ali J Marian  1
Affiliations

Update on hypertrophic cardiomyopathy

Ali J Marian. Tex Heart Inst J. 2010.
No abstract available

PubMed Disclaimer

Figures

None
Fig. 1 Pathogenesis of hypertrophic cardiomyopathy. The causal mutations alter the structure and function of the sarcomeres and impart various stresses on cardiac myocytes (mechanical, biochemical, bioenergetic, and others). The stress leads to the activation of signaling molecules that mediate the induction of cardiac myocyte hypertrophy, fibrosis, and other aspects of the gross cardiac phenotype.
See this image and copyright information in PMC

References

    1. Maron BJ. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002;287(10):1308–20. - PubMed
    1. Marian AJ. Genetic determinants of cardiac hypertrophy. Curr Opin Cardiol 2008;23(3):199–205. - PMC - PubMed
    1. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980–2006. Circulation 2009;119 (8):1085–92. - PubMed
    1. Marian AJ. Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy. Lancet 2000; 355(9197):58–60. - PubMed
    1. Patel R, Nagueh SF, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen HA, et al. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation 2001;104(3):317–24. - PMC - PubMed

MeSH terms

Substances