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. 2010 Apr;34(2):95-100.
doi: 10.4093/kdj.2010.34.2.95. Epub 2010 Apr 30.

Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients

Eun Hee Kim  1 , Ji Hee Yu, Sang Ah Lee, Eui Young Kim, Won Gu Kim, Seung Hun Lee, Eun Hee Cho, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
Affiliations

Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients

Eun Hee Kim et al. Korean Diabetes J. 2010 Apr.

Abstract

Background: Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy.

Methods: We conducted a case-control study to assess the relationship between serum cystatin C level and coronary artery disease in diabetic patients. Among 460 diabetic patients, 38 diabetic patients had CAD. The control group consisted of 38 diabetic patients who were matched to cases by age, sex, and presence/absence of diabetic nephropathy. Serum cystatin C level was measured in stored samples.

Results: Serum cystatin C level was significantly higher in patients with diabetic nephropathy, both in CAD and non-CAD patients. However, serum cystatin C level did not differ between CAD and non-CAD patients, regardless of diabetic nephropathy.

Conclusion: Serum cystatin C level is a marker of renal dysfunction, but not coronary artery disease, in diabetic patients.

Keywords: Coronary artery disease; Cystatin C; Diabetes mellitus; Diabetic nephropathies.

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