Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Feb;21(1):53-5.
doi: 10.5021/ad.2009.21.1.53. Epub 2009 Feb 28.

A case of isolated plexiform neurofibroma in a patient with myasthenia gravis

Seung Ju Back  1 , Dae Hun Kim, Nari Kim, Young Lee, Young Joon Seo, Jang Kyu Park, Jeung Hoon Lee
Affiliations
Case Reports

A case of isolated plexiform neurofibroma in a patient with myasthenia gravis

Seung Ju Back et al. Ann Dermatol. 2009 Feb.

Abstract

We report a case of an isolated plexiform neurofibroma occurring in a patient with myasthenia gravis. A 48-year-old man presented with asymptomatic skin-colored nodules on the tip of his 4th finger. Microscopically, a plexiform neurofibroma was identified located in the dermis that appeared to originate from small superficial nerves. He had a 20-year history of treated myasthenia gravis; otherwise, his personal and family histories were unremarkable. Given that myasthenia gravis is a disorder of the peripheral nerves, plexiform neurofibromas could be associated with myasthenia gravis. However, the development of an isolated plexiform neurofibroma in a case of myasthenia gravis has not yet been reported. The occurrence of a neurofibromas in a patient with myasthenia gravis suggests a link in the pathogenesis of these two diseases.

Keywords: Isolated; Myasthenia gravis; Plexiform neurofibroma.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
0.7×0.5 cm sized rubbery nodule on right fourth finger tip.
Fig. 2
Fig. 2
(A) Well circumscribed numerous nerve fascicles with irregular configurations embedded in cellular matrices (H&E stain, ×40). (B) Spindle shaped cells with wavy collagen fibrils in myxoid stroma (H&E stain, ×100). (C) Numerous cells of the fascicles present intensive positivity for S-100 protein (S100 stain, ×200).
See this image and copyright information in PMC

References

    1. Robert L, Joel C. The neurofibromatoses. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's dermatology in general medicine. 7th ed. New York: McGraw-Hill; 2008. pp. 1332–1334.
    1. Legius E, Descheemaeker MJ, Fryns JP, Van den Berghe H. Neurofibromatosis type 1. Genet Couns. 1994;5:225–241. - PubMed
    1. Kubota A, Komiyama A, Hasegawa O. Myasthenia gravis and alopecia areata. Neurology. 1997;48:774–775. - PubMed
    1. Younus J, Ahmed AR. The relationship of pemphigus to neoplasia. J Am Acad Dermatol. 1990;23:498–502. - PubMed
    1. Kwan SY, Lin JH, Su MS. Coexistence of epilepsy, myasthenia gravis and psoriasis vulgaris. Zhonghua Yi Xue Za Zhi (Taipei) 2000;63:153–157. - PubMed

Publication types