Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Feb;22(1):48-50.
doi: 10.5021/ad.2010.22.1.48. Epub 2010 Feb 28.

A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum

Jong Won Seo  1 , Hyun Ho Son, Joon Hee Choi, Sook Kyung Lee
Affiliations
Case Reports

A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum

Jong Won Seo et al. Ann Dermatol. 2010 Feb.

Abstract

Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who presented with cutaneous manifestations of pyoderma gangrenosum with simultaneous development of p-ANCAs during PTU therapy for Graves' disease.

Keywords: Propylthiouracil; Pyoderma gangrenosum; p-ANCA.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
(A) Initial presentation, 20×10 cm solitary ulcer on the right flank had a violaceous border. (B) Six months after discontinuation of PTU, marked healing of the wound was observed.
Fig. 2
Fig. 2
(A) There are dense inflammatory infiltrates throughout the dermis and subcutis (H&E, ×20). (B) Perivascular mixed cell infiltrates with some vascular damage in the papillary dermis (H&E, ×400). (C) Dense neutrophilic and eosinophilic infiltrates with leukocytoclasia and collagen degeneration in the reticular dermis (H&E, ×400).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Darben T, Savige J, Prentice R, Paspaliaris B, Chick J. Pyoderma gangrenosum with secondary pyarthrosis following propylthiouracil. Australas J Dermatol. 1999;40:144–146. - PubMed
    1. Miller RM, Darben TA, Nedwich J, Savige J. Propylthiouracil-induced antineutrophil cytoplasmic antibodies in a patient with Graves' disease and a neutrophilic dermatosis. Br J Dermatol. 1999;141:943–944. - PubMed
    1. Hong SB, Lee MH. A case of propylthiouracil-induced pyoderma gangrenosum associated with antineutrophil cytoplasmic antibody. Dermatology. 2004;208:339–341. - PubMed
    1. Gungor K, Gonen S, Kisakol G, Dikbas O, Kaya A. ANCA positive propylthiouracil induced pyoderma gangrenosum. J Endocrinol Invest. 2006;29:575–576. - PubMed
    1. Jacobs EM, Hartkamp A, Kaasjager HA. PTU-associated cutaneous vasculitis with ANCA anti-MPO and anti-PR3 antibodies. Neth J Med. 2003;61:296–299. - PubMed

Publication types