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Case Reports
. 2010 Feb;22(1):48-50.
doi: 10.5021/ad.2010.22.1.48. Epub 2010 Feb 28.

A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum

Jong Won Seo  1 , Hyun Ho Son, Joon Hee Choi, Sook Kyung Lee
Affiliations
Case Reports

A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum

Jong Won Seo et al. Ann Dermatol. 2010 Feb.

Abstract

Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who presented with cutaneous manifestations of pyoderma gangrenosum with simultaneous development of p-ANCAs during PTU therapy for Graves' disease.

Keywords: Propylthiouracil; Pyoderma gangrenosum; p-ANCA.

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Figures

Fig. 1
Fig. 1
(A) Initial presentation, 20×10 cm solitary ulcer on the right flank had a violaceous border. (B) Six months after discontinuation of PTU, marked healing of the wound was observed.
Fig. 2
Fig. 2
(A) There are dense inflammatory infiltrates throughout the dermis and subcutis (H&E, ×20). (B) Perivascular mixed cell infiltrates with some vascular damage in the papillary dermis (H&E, ×400). (C) Dense neutrophilic and eosinophilic infiltrates with leukocytoclasia and collagen degeneration in the reticular dermis (H&E, ×400).
See this image and copyright information in PMC

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