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Case Reports
. 2010 Feb;22(1):77-80.
doi: 10.5021/ad.2010.22.1.77. Epub 2010 Feb 28.

Diffuse cutaneous mastocytosis with generalized bullae

Eui Hyung Lee  1 , Mi Ri Kim, Tae Won Kang, Soo-Chan Kim
Affiliations
Case Reports

Diffuse cutaneous mastocytosis with generalized bullae

Eui Hyung Lee et al. Ann Dermatol. 2010 Feb.

Abstract

We report on a 9-month-old female infant with multiple tense bullae and erosions covering the entire body, including the face, scalp, and trunk. The histopathological examination revealed sub-epidermal bullae with a dense dermal cellular infiltrate. The infiltrate was identified as a collection of mast cells using toluidine blue and Giemsa stains. The direct immunofluorscence was negative. A diagnosis of cutaneous diffuse mastocytosis with generalized bullae was made based on these clinical and histopathological findings. In cases with diffuse cutaneous mastocytosis with generalized bullae, systemic involvement is more frequent and more severe compared to other types of cutaneous mastocytosis. Some lethal outcomes have been reported. This is the first reported case of diffuse cutaneous mastocytosis in the Korean literature.

Keywords: Diffuse cutaneous mastocytosis; Generalized bullae.

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Figures

Fig. 1
Fig. 1
(A, B) Multiple tense bullae and erosions developed with peau d'orange-like skin on the face, scalp, and trunk. (C) Darier's sign was positive on the thigh.
Fig. 2
Fig. 2
(A) Sub-epidermal bullae with a dense cellular infiltration in the upper dermis (H&E, ×200) and (B) dense mast cell infiltration with some eosinophils in the upper dermis (H&E, ×400).
Fig. 3
Fig. 3
Mast cells were stained with toluidine blue (A: ×200) and Giemsa stains (B: ×200).
See this image and copyright information in PMC

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