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Case Reports
. 2010 Feb;22(1):102-5.
doi: 10.5021/ad.2010.22.1.102. Epub 2010 Feb 28.

A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation

Jae-Jeong Park  1 , Sook Jung Yun, Jee-Bum Lee, Seong-Jin Kim, Young Ho Won, Seung-Chul Lee
Affiliations
Case Reports

A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation

Jae-Jeong Park et al. Ann Dermatol. 2010 Feb.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.

Keywords: Acute generalized exanthematous pustulosis; Adverse drug reactions; Hydroxychloroquine; Provocation test.

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Figures

Fig. 1
Fig. 1
Numerous erythematous, nonfollicular pustules on the whole body and note the diffuse superficial desquamation. (A) Face, (B) Trunk, (C) Arm.
Fig. 2
Fig. 2
Spongiform intraepidermal pustules and a perivascular infiltrate in the upper dermis (H&E, A: ×40, B: ×100, C: ×200).
See this image and copyright information in PMC

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