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Case Reports
. 2010 May;22(2):196-8.
doi: 10.5021/ad.2010.22.2.196. Epub 2010 May 18.

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement

Young Soo Heo  1 , Soo Bin Son, Jeong Eun Kim, Chil Hwan Oh, Hae Jun Song
Affiliations
Case Reports

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement

Young Soo Heo et al. Ann Dermatol. 2010 May.

Abstract

Kikuchi's disease (KD), or histiocytic necrotizing lymphadenitis, is a rare, self-limited lymphadenopathy, typically in young women, that usually remits spontaneously and does not recur. KD is clinically characterized by cervical lymphadenopathy and a high fever. Extranodal involvement (skin, arthritis, meningitis) rarely occurs. When KD is involved in a skin lesion, it presents with various shapes, but rarely manifests with symmetrically distributed, erythematous, firm nodules only on the face. In this report, we describe a patient with KD and unique skin manifestations.

Keywords: Cutaneous involvement; Histiocytic necrotizing lymphadenitis; Kikuchi's disease.

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Figures

Fig. 1
Fig. 1
Symmetrically distributed erythematous firm nodules measuring 8 mm in diameter are seen on both cheeks.
Fig. 2
Fig. 2
(A) Patchy infiltration of mononuclear cells around skin appendages and blood vessels (H&E, ×40). (B) Infiltrating cells are composed of large, atypical lymphocytes, histiocytes with crescent-shaped nuclei, and many apoptotic cells (H&E, ×200). (C) The histiocytic cells are positive for CD68 (×100).
See this image and copyright information in PMC

References

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    1. Chae KO, Baek SC, Byun DG, Park HJ. A case of Kikuchi's disease associated with systemic lupus erythematosus. Korean J Dermatol. 2001;39:483–486.

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