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Case Reports
. 2010 May;22(2):206-8.
doi: 10.5021/ad.2010.22.2.206. Epub 2010 May 18.

Atypical porokeratosis developing following bone marrow transplantation in a patient with myelodysplastic syndrome

Sang Hee Cha  1 , Hyun Jeong Park, Jun Young Lee, Baik Kee Cho
Affiliations
Case Reports

Atypical porokeratosis developing following bone marrow transplantation in a patient with myelodysplastic syndrome

Sang Hee Cha et al. Ann Dermatol. 2010 May.

Abstract

Porokeratosis is an abnormal disease of keratinization of epidermis. It is clinically characterized by margins covered with keratin layer and it typically has an atrophied macule with a protruded, circular form. Histopathologically, it shows the findings of cornoid lamella. Risk factors for its development include organ transplantation, long-term use of corticosteroids, immunocompromised status, including AIDS, and exposure to ultraviolet light. We herein report a case of atypical porokeratosis in a 38-year-old man who developed porokeratosis involving multiple sites following bone marrow transplantation for myelodysplastic syndrome.

Keywords: Bone marrow transplantation; Myelodysplastic syndrome; Porokeratosis.

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Figures

Fig. 1
Fig. 1
(A) Asymptomatic, multiple, slowly spreading, 0.5~2.5 cm, brownish to erythematous papules and plaques widely distributed on the body for 8 years. (B) Erythematous plaque with central atrophy and peripheral ridge. (C) Lesion was followed clinically without specific therapy for 6 months.
Fig. 2
Fig. 2
Typical cornoid lamella characteristic of porokeratosis (H&E, ×100).
See this image and copyright information in PMC

References

    1. Schamroth JM, Zlotogorski A, Gilead L. Porokeratosis of Mibelli. Overview and review of the literature. Acta Derm Venereol. 1997;77:207–213. - PubMed
    1. Alexis AF, Busam K, Myskowski PL. Porokeratosis of Mibelli following bone marrow transplantation. Int J Dermatol. 2006;45:361–365. - PubMed
    1. Levin RM, Heymann WR. Superficial disseminate porokeratosis in a patient with myelodysplastic syndrome. Int J Dermatol. 1999;38:138–139. - PubMed
    1. Herranz P, Pizarro A, De Lucas R, Robayna MG, Rubio FA, Sanz A, et al. High incidence of porokeratosis in renal transplant recipients. Br J Dermatol. 1997;136:176–179. - PubMed
    1. Lederman JS, Sober AJ, Lederman GS. Immunosuppression: a cause of porokeratosis? J Am Acad Dermatol. 1985;13:75–79. - PubMed

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