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Comparative Study
. 2010 Jun-Jul;26(6):201-5.
doi: 10.1016/s0828-282x(10)70400-1.

Dose-response relationship between physical activity and dyslipidemia in youth

Allana G LeBlanc  1 , Ian Janssen
Affiliations
Comparative Study

Dose-response relationship between physical activity and dyslipidemia in youth

Allana G LeBlanc et al. Can J Cardiol. 2010 Jun-Jul.

Abstract
in English, French

Background: The minimal and optimal amount of physical activity associated with cardiovascular health benefits in young people is unknown.

Objective: To determine the dose-response relationship between moderate-to-vigorous physical activity (MVPA) with high-risk low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride values in youth.

Methods: The study sample consisted of 1235 adolescents (12 to 19 years of age) from the 20032004 and 20052006 cycles of the United States National Health and Nutrition Examination Survey. Objective measures of MVPA were obtained over seven days with accelerometers. LDL cholesterol, HDL cholesterol and triglycerides were measured from a fasting blood sample. High-risk values for these lipidslipoproteins were determined using age- and sex-specific thresholds. Logistic regression models were used to determine the dose-response relationships between MVPA and high-risk lipid levels.

Results: ORs for high-risk HDL cholesterol and triglyceride values decreased in a curvilinear manner with increasing minutes of MVPA. Compared with no MVPA (0 min), the ORs for high-risk HDL cholesterol values at 15 min, 30 min and 60 min per day of MVPA were 0.29 (95% CI 0.13 to 0.67), 0.24 (95% CI 0.10 to 0.64) and 0.21 (95% CI 0.07 to 0.61), respectively. The corresponding ORs for high-risk triglyceride values were 0.40 (95% CI 0.18 to 0.76), 0.22 (95% CI 0.06 to 0.66) and 0.10 (95% CI 0.01 to 0.51). There was no discernible dose-response relationship between MVPA and LDL cholesterol.

Conclusions: Small amounts of MVPA were associated with a large reduction in the likelihood of having high-risk HDL cholesterol and triglyceride values in this representative sample of adolescents.

HISTORIQUE :: On ne connaît pas la quantité minimale et optimale d’activité physique qui s’associe à des bienfaits sur la santé cardiovasculaire chez les jeunes.

OBJECTIF :: Déterminer la relation dose-effet entre une activité physique modérée à vigoureuse (APMV) et les valeurs de cholestérol à lipoprotéines de basse densité (LDL), de cholestérol à lipoprotéines de haute densité (HDL) et de triglycérides chez les jeunes.

MÉTHODOLOGIE :: L’échantillon de l’étude se composait de 1 235 adolescents (de 12 à 19 ans) ayant participé aux cycles 2003–2004 et 2005–2006 de la National Health and Nutrition Examination Survey des États-Unis. Les chercheurs ont obtenu des mesures objectives de l’APMV pendant sept jours à l’aide d’accéléromètres. Ils ont mesuré le cholestérol LDL, le cholestérol HDL et les triglycérides à partir d’un échantillon de glycémie à jeun. Ils ont déterminé les valeurs à haut risque de ces lipides et lipoprotéines au moyen de seuils propres à l’âge et au sexe. Ils ont utilisé les modèles de régression logistique pour déterminer la relation dose-effet entre l’APMV et les taux de lipides à haut risque.

RÉSULTATS :: Les RRR des valeurs de cholestérol HDL et de triglycérides à haut risque ont diminué de manière curvilinéaire avec l’augmentation des minutes d’APMV. Par rapport à l’absence d’APMV (0 min), les valeurs du RRR de cholestérol HDL à haut risque en cas d’APMV 15 min, 30 min et 60 min par jour s’élevaient à 0,29 (95 % IC 0,13 à 0,67), 0,24 (95 % IC 0,10 à 0,64) et 0,21 (95 % IC 0,07 à 0,61), respectivement. Les RRR correspondant aux valeurs des triglycérides à haut risque s’élevaient à 0,40 (95 % IC 0,18 à 0,76), 0,22 (95 % IC 0,06 à 0,66) et 0,10 (95 % IC 0,01 à 0,51). Il n’y avait pas de relation dose-effet discernable entre l’APMV et le cholestérol LDL.

CONCLUSIONS :: De petites quantités d’APMV s’associaient à une importante réduction de la probabilité de présenter des valeurs de cholestérol HDL et de triglycérides à haut risque dans cet échantillon représentatif d’adolescents.

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Figures

Figure 1)
Figure 1)
Odds ratio (OR) for high-risk low-density lipoprotein (LDL) cholesterol values (Panel A), high-risk high-density lipoprotein (HDL) cholesterol values (Panel B) and high-risk triglyceride values (Panel C) according to average min/day of moderate-to-vigorous physical activity (MVPA). A value of 1 min/day represents the referent value (OR 1.0) for MVPA. Solid lines represent the predicted ORs and dotted lines represent the 95% CIs
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