Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun 15:4:178.
doi: 10.1186/1752-1947-4-178.

Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens' Double Glucagon Antibody and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon: a case report

Wesley B Vanderlan  1 , Ziying Zhang, Marwan S Abouljoud
Affiliations

Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens' Double Glucagon Antibody and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon: a case report

Wesley B Vanderlan et al. J Med Case Rep. .

Abstract

Introduction: This case report demonstrates that the differential immunohistochemical reactivities of Siemens' Double Antibody Glucagon compared to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon allow for pathologic distinction of enteral versus pancreatic glucagonoma.

Case presentation: A 64-year-old Caucasian man was diagnosed with a duodenal enteroglucagonoma following presentation with obstructive jaundice. He had a low serum glucagon level using Siemens' Double Antibody Glucagon, a clinical syndrome consistent with glucagon hypersecretion. A periampullary mass biopsy proved to be a neuroendocrine tumor, with positive immunohistochemical reactivity to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon.

Conclusions: Differential comparison of the immunohistochemical reactivities of Siemens' Double Antibody Glucagon and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon discerns enteroglucagon from pancreatic glucagon.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Oberg K, Eriksson B. Endocrine tumours of the pancreas. Best Pract Res Clin Gastroenterol. 2005;19(5):753–781. doi: 10.1016/j.bpg.2005.06.002. - DOI - PubMed
    1. Roggli VL, Judge DM, McGavran MH. Duodenal glucagonoma: a case report. Hum Pathol. 1979;10(3):350–353. doi: 10.1016/S0046-8177(79)80032-5. - DOI - PubMed
    1. Mansour JC, Chen H. Pancreatic endocrine tumors. J Surg Res. 2004;120(1):139–161. doi: 10.1016/j.jss.2003.12.007. - DOI - PubMed
    1. Stacpoole PW. The glucagonoma syndrome: clinical features diagnosis, and treatment. Endocr Rev. 1981;2(3):347–361. doi: 10.1210/edrv-2-3-347. - DOI - PubMed
    1. Pech O, Lingenfelser T, Wunsch P. Pancreatic glucagonoma as a rare cause of chronic obstructive pancreatitis. Gastrointest Endosc. 2000;52(4):562–564. doi: 10.1067/mge.2000.105733. - DOI - PubMed

LinkOut - more resources