Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Mar;19(3):903-7.
doi: 10.1128/iai.19.3.903-907.1978.

Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus

G C Tarr, J A Armstrong, M Ho

Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus

G C Tarr et al. Infect Immun. 1978 Mar.

Abstract

Mice injected intraperitoneally with murine cytomegalovirus produced as many as 1,000 U of serum interferon. The response appeared biphasic, with maximum titers in the first phase detectable from 2 through 4 days after infection. A second phase peaked 10 days after infection. By carboxyhexyl-Sepharose affinity chromatography, the serum interferon behaved like lymphocyte interferon. The infected mice also produced substantial quantities of serum hyporeactivity factor (D.A. Stringfellow, E.R. Kern, D.K. Kelsey, and L.A. Glasgow, J. Infect. Dis. 135:540-551, 1977), although always in the presence of interferon. This factor was separated from the serum interferon by concanavalin A-Sepharose affinity chromatography.

PubMed Disclaimer

References

    1. J Virol. 1976 Feb;17(2):439-45 - PubMed
    1. Infect Immun. 1977 Sep;17(3):572-9 - PubMed
    1. Infect Immun. 1977 Jan;15(1):78-83 - PubMed
    1. Infect Immun. 1976 Feb;13(2):392-8 - PubMed
    1. J Infect Dis. 1977 Apr;135(4):540-51 - PubMed

Publication types

LinkOut - more resources