ATM Creates a veil of transcriptional silence
- PMID: 20550929
- DOI: 10.1016/j.cell.2010.05.035
ATM Creates a veil of transcriptional silence
Abstract
The ATM kinase orchestrates diverse responses to DNA damage. By simultaneously monitoring transcription and DNA-damage responses in single cells, Shanbhag et al. (2010) now uncover a role of ATM in preventing transcription near DNA double-strand breaks.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.Cell. 2010 Jun 11;141(6):970-81. doi: 10.1016/j.cell.2010.04.038. Cell. 2010. PMID: 20550933 Free PMC article.
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