Review
doi: 10.1152/physiol.00049.2009.
Calcium signaling through CatSper channels in mammalian fertilization
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- PMID: 20551230
- DOI: 10.1152/physiol.00049.2009
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Review
Calcium signaling through CatSper channels in mammalian fertilization
Physiology (Bethesda).
2010 Jun.
Free article
Abstract
The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought.
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