doi: 10.1016/0014-2999(91)90156-k.
Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat
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- PMID: 2055248
- DOI: 10.1016/0014-2999(91)90156-k
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Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat
Eur J Pharmacol.
.
Abstract
Peripheral administration of cholecystokinin tetrapeptide (CCK-4) at non-sedative doses (25-50 micrograms/kg) decreased the exploratory activity of rats in an elevated plus-maze. This effect was antagonized by treatment with CCK receptor antagonists proglumide (1 and 10 mg/kg), lorglumide (0.1 and 1 mg/kg), L 365,260 (10 micrograms/kg) and devazepide (1 mg/kg). The results suggest that the exploratory behaviour of rats can be altered by pharmacological manipulations at CCK-B receptors.
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